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Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, Tag Free&Tag Free

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分子别名(Synonym)

Integrin alpha V beta 1,ITGAV&ITGB1

表达区间及表达系统(Source)

Human ITGAV&ITGB1 Heterodimer Protein, Tag Free&Tag Free (IT1-H5213) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1) (Accession # NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1)).

Predicted N-terminus: Phe 31 (ITGAV) & Gln 21 (ITGB1)

蛋白结构(Molecular Characterization)

Online-Res(Phe 31 - Val 992 (ITGAV) & Gln 21 - Asp 728 (ITGB1)) NP_002201.1 (ITGAV) & NP_002202.2 (ITGB1)

Human ITGAV&ITGB1 Heterodimer Protein, Tag Free&Tag Free, produced by co-expression of ITGAV and ITGB1, has a calculated MW of 112.9 kDa (ITGAV) and 83.7 kDa (ITGB1). Subunit ITGAV contains no tag but an acidic tail at the C-terminus and subunit ITGB1 contains no tag but a basic tail at the C-terminus.

内毒素(Endotoxin)

制剂(Formulation)

Lyophilized from 0。22 μm filtered solution in 50 mM Tris, 150 mM NaCl, 2 mM CaCl2, pH7。5。 Normally trehalose is added as protectant before lyophilization。

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower。

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Integrin alpha-5/beta-1 is a receptor for ibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-V/beta-1 is also a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition.

 

前沿进展

货号/价格

IT1-H5213-100ug / ¥4100

IT1-H5213-1mg / ¥28800

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