搜索
 >  其他蛋白>IL-13 R alpha 2 >Human IL-13 R alpha 2 Protein, His Tag

Human IL-13 R alpha 2 Protein, His Tag

此产品为在研产品。如果您对此产品有兴趣,请直接联系我们。我们会根据您的需求相应地加速我们的研发进程,并为您进行产品预留。

分子别名(Synonym)

IL13RA2,CD213A2,CT19,IL-13R,IL13BP

表达区间及表达系统(Source)

Human IL-13 R alpha 2 Protein, His Tag (IL2-H52H5) is expressed from human 293 cells (HEK293). It contains AA Asp 27 - Arg 343 (Accession # Q14627-1).

Predicted N-terminus: Asp 27

蛋白结构(Molecular Characterization)

Online-Res(Asp 27 - Arg 343) Q14627-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 39.0 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Lyophilized from 0。22 μm filtered solution in PBS, pH7。4。 Normally trehalose is added as protectant before lyophilization。

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene。 IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex。 This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator。 It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter。 It is also reported to play a role in the internalization of IL13。 IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1。 It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain。 In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis。 Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme。

 

前沿进展

货号/价格

IL2-H52H5-100ug / ¥3000

IL2-H52H5-1mg / ¥18000

开发建议
文档
联系电话:
400-682-2521(全国)
010-57737274(北京)
021-26136428(上海)
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
techsupport@acrobiosystems.com

消息提示

请输入您的联系方式,再点击提交!

确定