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FGL1蛋白:LAG-3免疫治疗新配体

背景
FGL1是纤维蛋白原蛋白质家族的成员。正常情况下,FGL1在肝脏低水平表达,但在前列腺癌、黑素瘤等许多类型的癌症中均高表达。最新研究表明,FGL1是LAG-3的主要配体并具有高亲和力,表明FGL1的发现将开启肿瘤免疫治疗新时代,为肿瘤的免疫治疗提供新契机。
为满足市场需求,ACROBiosystems开发了由HEK293表达的多种属(Human, Mouse, Cyno)和多种标签(Fc, His)的FGL1重组蛋白,更有AviTagTM生物素标记的FGL1蛋白可以助力于您的药物开发。ACRO对FGL1蛋白的纯度、活性等性能进行了验证,并可免费提供相应的Protocol。
应用
产品列表
Molecule Cat. No. Host Product Description Product Status
FGL1
(HEK293表达)
FG1-H52Hy Human Human FGL1 Protein, His Tag Launched
FG1-H5258 Human Human FGL1 Protein, Fc Tag
FG1-H82F4 Human Biotinylated Human FGL1 Protein, Avitag™,Fc Tag
FG1-M5255 Mouse Mouse FGL1 Protein, Fc Tag
FG1-C5253 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque FGL1 Protein, Fc Tag
FG1-H82Ey Human Biotinylated Human FGL1 Protein, His,Avitag™ Coming soon
FG1-M5253 Mouse Mouse FGL1 Protein, Mouse IgG2a Fc Tag
FG1-C5256 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque FGL1 Protein, Mouse IgG2a Fc Tag

FGL1被鉴定为LAG-3的主要配体,如果您同时对LAG-3感兴趣,可以点击获得更多LAG-3产品的相关信息。

活性验证
FGL1的生物活性验证

Immobilized Human LAG-3, Llama IgG2b Fc Tag, low endotoxin (Cat. No. LA3-H525c) at 5 μg/mL (100 μL/well) can bind Biotinylated Human FGL1, Avitag,Fc Tag (Cat. No. FG1-H82F4) with a linear range of 0.313-2.5 μg/mL.

Protocol

Loaded Biotinylated Human FGL1, Avitag,Fc Tag (Cat. No. FG1-H82F4) on SA Biosensor, can bind Human LAG-3, Fc Tag (Cat. No. LA3-H5255) with an affinity constant of 2.63 nM as determined in BLI assay (ForteBio Octet Red96e).

Protocol

Immobilized Mouse LAG-3, His Tag (Cat. No. LA3-M52H5) at 20 μg/mL (100 μL/well) can bind Mouse FGL1, Fc Tag (Cat. No. FG1-M5255) with a linear range of 0.078-1.25 μg/mL.

Protocol

Immobilized Human LAG-3, mouse IgG2a Fc tag (Cat. No. LA3-H52Aa) at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque FGL1, Fc Tag (Cat. No. FG1-C5253) with a linear range of 8-125 ng/mL.

Protocol

*如果您希望ACRO补充更多FGL1产品的实验设计和应用数据,请 点击咨询

*如果您对ACRO有新品开发建议或者对FGL1蛋白有增项建议,请点击 开发建议

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